Beilstein J. Org. Chem.2018,14, 309–317, doi:10.3762/bjoc.14.19
)-GABOB.
Keywords: alcoholysis desymmetrization; bifunctionalorganocatalysis; chloramphenicol base; Introduction
Over the past decade, remarkable advances in the utilization of natural products as chiral structural motifs for the design of bifunctional organocatalysts have been achieved. A high
different alcohols (Table 3). Excellent yields with high enantioselectivities were obtained in all cases. The sterically more bulky 2-propanol worked well in this reaction. Allylic alcohol, benzyl alcohol and cinnamyl alcohol were also well compatible in this bifunctionalorganocatalysis conditions to
Beilstein J. Org. Chem.2016,12, 505–523, doi:10.3762/bjoc.12.50
; bifunctional; organocatalysis; hydrogen bonding; Introduction
The structural and chemical properties of the 1,2-aminoindanol scaffold 1 have transformed aminoindanol derivatives into versatile building blocks for the construction of catalysts and the efficient induction of chirality in asymmetric processes
PDF
Graphical Abstract
Figure 1:
Different configurations of 1,2-aminoindanol 1a–d.